297004

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1373702..1374972 Replicon chromosome
Accession NZ_OX460934
Organism Streptococcus agalactiae isolate MRI Z2-335

Toxin (Protein)


Gene name sezT Uniprot ID A0A4V0H7E2
Locus tag QOR46_RS07080 Protein ID WP_017648279.1
Coordinates 1373702..1374496 (-) Length 265 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag QOR46_RS07085 Protein ID WP_017648280.1
Coordinates 1374496..1374972 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOR46_RS07070 1370030..1372102 - 2073 WP_069987943.1 AAA family ATPase -
QOR46_RS07075 1372406..1373636 + 1231 Protein_1316 IS110 family transposase -
QOR46_RS07080 1373702..1374496 - 795 WP_017648279.1 type II toxin-antitoxin system toxin PezT Toxin
QOR46_RS07085 1374496..1374972 - 477 WP_017648280.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
QOR46_RS07090 1375042..1375332 - 291 WP_017648281.1 hypothetical protein -
QOR46_RS07095 1375382..1375771 - 390 WP_017648282.1 DUF5945 family protein -
QOR46_RS07100 1375768..1375995 - 228 WP_017648283.1 DUF5965 family protein -
QOR46_RS07105 1376049..1377125 - 1077 WP_017648284.1 toprim domain-containing protein -
QOR46_RS07110 1377165..1377803 - 639 WP_283571892.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 265 a.a.        Molecular weight: 30314.37 Da        Isoelectric Point: 6.7533

>T297004 WP_017648279.1 NZ_OX460934:c1374496-1373702 [Streptococcus agalactiae]
MRLEEFSKADFQKALQRTIRALTRGKTIPDRPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQIAQLLASKGYQISLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDCIQIYQRDRTCIYNSETDEGSAAEVLQECLFGKWSKVEEEMM
KAGQERLRELCNRDREEKFEKNKS

Download         Length: 795 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18303.73 Da        Isoelectric Point: 4.4582

>AT297004 WP_017648280.1 NZ_OX460934:c1374972-1374496 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVTTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSHNIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERILDMVYHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0H7E2

Antitoxin

Source ID Structure

References