Detailed information of TA system TA297002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-HTH_XRE
• Location: 1087729..1088972
• Replicon: chromosome
• Accession: NZ_OX460934
• Organism: Streptococcus agalactiae isolate MRI Z2-335

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: QOR46_RS05645
• Protein ID: WP_001235244.1
• Coordinates: 1087729..1088496 (-)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: QOR46_RS05650
• Protein ID: WP_000578717.1
• Coordinates: 1088496..1088972 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR46_RS05630	1084121..1084486	-	366	WP_000431638.1	MobC family plasmid mobilization relaxosome protein	-
QOR46_RS05635	1084496..1084855	-	360	WP_000806607.1	SAG1252 family conjugative relaxosome accessory protein	-
QOR46_RS05640	1085186..1087693	-	2508	WP_001213956.1	AAA family ATPase	-
QOR46_RS05645	1087729..1088496	-	768	WP_001235244.1	type II toxin-antitoxin system toxin PezT	Toxin
QOR46_RS05650	1088496..1088972	-	477	WP_000578717.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
QOR46_RS05655	1089042..1089332	-	291	WP_283571868.1	hypothetical protein	-
QOR46_RS05660	1089382..1089771	-	390	WP_000048069.1	DUF5945 family protein	-
QOR46_RS05665	1089768..1089995	-	228	WP_000110922.1	DUF5965 family protein	-
QOR46_RS05670	1090049..1091125	-	1077	WP_000196864.1	toprim domain-containing protein	-
QOR46_RS05675	1091165..1091803	-	639	WP_000933072.1	hypothetical protein	-
QOR46_RS05680	1091899..1092189	-	291	WP_000893088.1	DUF5966 family protein	-
QOR46_RS05685	1092203..1092502	-	300	WP_000079456.1	DUF5962 family protein	-
QOR46_RS05690	1092573..1093421	-	849	Protein_1042	helicase SNF2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 29034.87 Da
• Isoelectric Point: 5.6973

>T297002 WP_001235244.1 NZ_OX460934:c1088496-1087729 [Streptococcus agalactiae]
MRLEEFSETDFQKALQRTIRAVTRGKTIPDKPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLGSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIAPNQARATPKEHHDGIVENLVDNLSELEREQLFDCIQIYQRDRTCIYDSKTYEGSAAEVLQNCLFGEWSKVEEEMM
KESELQLNELLEKNK

Nucleotide

• Length: 768 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18328.84 Da
• Isoelectric Point: 4.5622

>AT297002 WP_000578717.1 NZ_OX460934:c1088972-1088496 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSKVSTELIDRICQKFNVSYIDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSKLYRYQDSQDIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp