Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1204690..1205960 Replicon chromosome
Accession NZ_OX460931
Organism Streptococcus agalactiae isolate MRI Z2-174

Toxin (Protein)


Gene name sezT Uniprot ID A0A4V0H7E2
Locus tag QOR44_RS06245 Protein ID WP_017648279.1
Coordinates 1204690..1205484 (-) Length 265 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag QOR44_RS06250 Protein ID WP_017648280.1
Coordinates 1205484..1205960 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOR44_RS06235 1201018..1203090 - 2073 WP_069987943.1 AAA family ATPase -
QOR44_RS06240 1203394..1204624 + 1231 Protein_1150 IS110 family transposase -
QOR44_RS06245 1204690..1205484 - 795 WP_017648279.1 type II toxin-antitoxin system toxin PezT Toxin
QOR44_RS06250 1205484..1205960 - 477 WP_017648280.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
QOR44_RS06255 1206030..1206320 - 291 WP_017648281.1 hypothetical protein -
QOR44_RS06260 1206370..1206759 - 390 WP_017648282.1 DUF5945 family protein -
QOR44_RS06265 1206756..1206983 - 228 WP_017648283.1 DUF5965 family protein -
QOR44_RS06270 1207037..1208113 - 1077 WP_017648284.1 toprim domain-containing protein -
QOR44_RS06275 1208153..1208791 - 639 WP_017648285.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 265 a.a.        Molecular weight: 30314.37 Da        Isoelectric Point: 6.7533

>T296999 WP_017648279.1 NZ_OX460931:c1205484-1204690 [Streptococcus agalactiae]
MRLEEFSKADFQKALQRTIRALTRGKTIPDRPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQIAQLLASKGYQISLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDCIQIYQRDRTCIYNSETDEGSAAEVLQECLFGKWSKVEEEMM
KAGQERLRELCNRDREEKFEKNKS

Download         Length: 795 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18303.73 Da        Isoelectric Point: 4.4582

>AT296999 WP_017648280.1 NZ_OX460931:c1205960-1205484 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVTTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSHNIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERILDMVYHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0H7E2

Antitoxin

Source ID Structure

References