Detailed information of TA system TA296998

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1293959..1295391
• Replicon: chromosome
• Accession: NZ_OX460911
• Organism: Streptococcus agalactiae isolate MRI Z2-322

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: Q8DZ35
• Locus tag: QOR55_RS06660
• Protein ID: WP_001030302.1
• Coordinates: 1294546..1295391 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q8DZ36
• Locus tag: QOR55_RS06655
• Protein ID: WP_000037239.1
• Coordinates: 1293959..1294549 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR55_RS06655	1293959..1294549	+	591	WP_000037239.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QOR55_RS06660	1294546..1295391	+	846	WP_001030302.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QOR55_RS06665	1295477..1298278	-	2802	WP_283572998.1	phage tail tip lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hylB / wbtL	1200530..1306587	106057

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-257)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32414.90 Da
• Isoelectric Point: 5.2111

>T296998 WP_001030302.1 NZ_OX460911:1294546-1295391 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITIIISTDSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23074.63 Da
• Isoelectric Point: 7.8056

>AT296998 WP_000037239.1 NZ_OX460911:1293959-1294549 [Streptococcus agalactiae]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Nucleotide

• Length: 591 bp

Structures

Toxin

• AlphaFold DB: A8D822

Antitoxin

• AlphaFold DB: A0A2I7ZET8