Detailed information of TA system TA296996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 359897..361245
• Replicon: chromosome
• Accession: NZ_OX460910
• Organism: Photobacterium phosphoreum strain MIP2473 isolate MIP2473

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: QOS47_RS16335
• Protein ID: WP_065191859.1
• Coordinates: 360304..361245 (+)
• Length: 314 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: A0A1T4TU77
• Locus tag: QOS47_RS16330
• Protein ID: WP_045029559.1
• Coordinates: 359897..360301 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOS47_RS16300	355180..355953	+	774	WP_045029565.1	molybdate ABC transporter substrate-binding protein	-
QOS47_RS16305	356143..356832	+	690	WP_045029563.1	molybdate ABC transporter permease subunit	-
QOS47_RS16310	356832..357932	+	1101	WP_065207594.1	molybdenum ABC transporter ATP-binding protein ModC	-
QOS47_RS16315	358109..358402	+	294	WP_045029560.1	Bor family protein	-
QOS47_RS16320	358527..358721	+	195	WP_065191857.1	hypothetical protein	-
QOS47_RS16325	359138..359730	+	593	Protein_243	tyrosine-type recombinase/integrase	-
QOS47_RS16330	359897..360301	+	405	WP_045029559.1	DUF6088 family protein	Antitoxin
QOS47_RS16335	360304..361245	+	942	WP_065191859.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QOS47_RS16340	361266..361388	+	123	Protein_246	type I restriction-modification system subunit M N-terminal domain-containing protein	-
QOS47_RS16345	361962..362900	+	939	WP_065191860.1	DUF4268 domain-containing protein	-
QOS47_RS16350	363254..365227	-	1974	WP_107293288.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
QOS47_RS16355	365224..366156	-	933	WP_065191862.1	iron-siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-300)

Antitoxin

• Protein of unknown function DUF6088 (7-130)

Sequences

Toxin

Protein

• Length: 314 a.a.
• Molecular weight: 36342.93 Da
• Isoelectric Point: 6.8373

>T296996 WP_065191859.1 NZ_OX460910:360304-361245 [Photobacterium phosphoreum]
MNKLKQQFLEVSDALALGNPAIIEKDYWVVALLAQLEKLIIDSHQLVFSGGTALAKSNVKIMRMSEDVDIKLIPNADFHT
LSRSKKKIVRKSLLETLEKSIRESNTFLIENKQAWDEYRYVEYDLKYPQQFSQAPCLRPIIKLELMETIPLQETEQRSIQ
SLVAELYQHTKEVKAFACISVHATLVEKIISMLRRTMLAKRDENRKDDQTLVRHIYDVYCIDKAQQVDIKSLSLLFNAVL
QEDITRFGNQHTEFVNNPSKELQDGLSELENNPLYRQRFDAFVTPMVFNQQPHDFDSCFASFKRIAELLIKTI

Nucleotide

• Length: 942 bp

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15278.58 Da
• Isoelectric Point: 10.4940

>AT296996 WP_045029559.1 NZ_OX460910:359897-360301 [Photobacterium phosphoreum]
MTTTDRIYQKIKRSRRYVFERKNFEGVACYDQVGRALKQLVNQGELMKIGYGLYTKSRMNSLTGKPMPTHPGGTDALMRE
ILKMKGVDFEIDSLSLQSLSGENTQIPSSINYSWNSKQFNRKLVVGSRVIHSPN

Nucleotide

• Length: 405 bp

Structures

Antitoxin

• AlphaFold DB: A0A1T4TU77