Detailed information of TA system TA296989

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 710358..711781
• Replicon: chromosome
• Accession: NZ_OX460906
• Organism: Streptococcus agalactiae isolate MRI Z2-265

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: QOR56_RS03815
• Protein ID: WP_111715775.1
• Coordinates: 710358..711194 (-)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: QOR56_RS03820
• Protein ID: WP_111715777.1
• Coordinates: 711191..711781 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QOR56_RS03785	705494..706687	+	1194	WP_000885817.1	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	-
QOR56_RS03790	706702..707172	+	471	WP_000152413.1	6,7-dimethyl-8-ribityllumazine synthase	-
QOR56_RS03795	707399..708409	-	1011	WP_283573750.1	site-specific integrase	-
QOR56_RS03800	708500..709644	+	1145	WP_088881664.1	IS3 family transposase	-
QOR56_RS03805	709672..709911	-	240	WP_283573751.1	integrase DNA-binding domain-containing protein	-
QOR56_RS03810	709976..710173	-	198	WP_006738512.1	excisionase	-
QOR56_RS03815	710358..711194	-	837	WP_111715775.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QOR56_RS03820	711191..711781	-	591	WP_111715777.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QOR56_RS03825	711894..713006	-	1113	WP_283573752.1	phage tail tip lysozyme	-
QOR56_RS03830	713025..713252	-	228	WP_017650313.1	hypothetical protein	-
QOR56_RS03835	713239..715152	-	1914	WP_070039954.1	PT domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	tufA	590051..778830	188779

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31937.34 Da
• Isoelectric Point: 5.1824

>T296989 WP_111715775.1 NZ_OX460906:c711194-710358 [Streptococcus agalactiae]
VNKAKLTALCHKVSKETGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVHQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDIYILSKLKKSEIDSQQLLTACQRTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23193.56 Da
• Isoelectric Point: 8.3205

>AT296989 WP_111715777.1 NZ_OX460906:c711781-711191 [Streptococcus agalactiae]
MSNKETVLNYLKQNNGIITYKDCKELGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGFTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVPKEIVDLGIISIKTPWGQTVKTYDFERIICDFIQNRKKIDNELFVKT
LKAYVNYPNKNLTNLYQYAEKMKIINQTKQTLEVLM

Nucleotide

• Length: 591 bp