Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4438515..4439137 Replicon chromosome
Accession NZ_OX458335
Organism Pseudomonas syringae pv. tomato strain DAPP-PG 215 isolate IPVPG 215

Toxin (Protein)


Gene name hicA Uniprot ID Q886E5
Locus tag QWJ11_RS20510 Protein ID WP_011103638.1
Coordinates 4438955..4439137 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q886E4
Locus tag QWJ11_RS20505 Protein ID WP_005767619.1
Coordinates 4438515..4438919 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QWJ11_RS20490 (DAPPPG215_20700) 4434285..4434953 + 669 WP_007245682.1 ABC transporter ATP-binding protein -
QWJ11_RS20495 (DAPPPG215_20705) 4434953..4437430 + 2478 WP_010202744.1 ABC transporter permease -
QWJ11_RS20500 (DAPPPG215_20710) 4437420..4438499 + 1080 WP_010202739.1 lipocalin-like domain-containing protein -
QWJ11_RS20505 (DAPPPG215_20715) 4438515..4438919 - 405 WP_005767619.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QWJ11_RS20510 4438955..4439137 - 183 WP_011103638.1 type II toxin-antitoxin system HicA family toxin Toxin
QWJ11_RS20515 (DAPPPG215_20725) 4439422..4441194 + 1773 WP_007245686.1 N-acetylglutaminylglutamine amidotransferase -
QWJ11_RS20520 (DAPPPG215_20730) 4441198..4442946 + 1749 WP_005767614.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6675.81 Da        Isoelectric Point: 10.6643

>T296985 WP_011103638.1 NZ_OX458335:c4439137-4438955 [Pseudomonas syringae pv. tomato]
VQSRQLVKELEADGWVLDRVTGSHHMFKHPEKSQTVPVPHPKKDLPLGTVKAIRKLAGLA

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14455.52 Da        Isoelectric Point: 4.9093

>AT296985 WP_005767619.1 NZ_OX458335:c4438919-4438515 [Pseudomonas syringae pv. tomato]
MKYPICIEWGDETTAFGIQIPDIPGAITAGDTFEEAHAAAVEIAHIMLQEIAASGGSIPKVGTVAEHAKNPDFSGMGWGM
LEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q886E5

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3Z2W9

References