Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-AbrB
Location 1591730..1592294 Replicon chromosome
Accession NZ_OX458332
Organism Methylococcus capsulatus isolate Mc(Nor)

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QMX71_RS07565 Protein ID WP_282213703.1
Coordinates 1591730..1592074 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q602Q6
Locus tag QMX71_RS07570 Protein ID WP_010962195.1
Coordinates 1592064..1592294 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMX71_RS07560 (MCNOR_1593) 1588743..1591733 - 2991 WP_282213702.1 DUF1156 domain-containing protein -
QMX71_RS07565 (MCNOR_1594) 1591730..1592074 - 345 WP_282213703.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QMX71_RS07570 (MCNOR_1595) 1592064..1592294 - 231 WP_010962195.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
QMX71_RS07575 (MCNOR_1596) 1592337..1596002 - 3666 WP_282213704.1 helicase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin

SpoVT-AbrB domain

(5-31)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 11972.97 Da        Isoelectric Point: 11.0291

>T296979 WP_282213703.1 NZ_OX458332:c1592074-1591730 [Methylococcus capsulatus]
VTYERGQVVRVPFPFTDRAASKNRPALVLSGASAFNTPAGHVVLAMITSAKNPPWPLDYPIEDLAAAGLPAPSVVRCKLF
TLDARLIRGVLGRLAAADAARANTALARLLGPLS

Download         Length: 345 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8275.34 Da        Isoelectric Point: 4.3855

>AT296979 WP_010962195.1 NZ_OX458332:c1592294-1592064 [Methylococcus capsulatus]
MTAVAKITAKGQTTIPADIRAALHVGPGDLIAWEIEPDGSARVRRVQPLDIEYLKAVEGTLSEWTSPADEEAYRDL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q602Q6

References