Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1420757..1421419 Replicon chromosome
Accession NZ_OX458331
Organism Anaerococcus sp. Marseille-Q7828

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QNH69_RS06765 Protein ID WP_282929738.1
Coordinates 1421225..1421419 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QNH69_RS06760 Protein ID WP_282929737.1
Coordinates 1420757..1421188 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH69_RS06740 1416695..1417816 - 1122 WP_282929735.1 glucose-1-phosphate adenylyltransferase subunit GlgD -
QNH69_RS06745 1417818..1418951 - 1134 WP_282929736.1 glucose-1-phosphate adenylyltransferase -
QNH69_RS06755 1419860..1420360 + 501 WP_084593708.1 IS200/IS605 family transposase -
QNH69_RS06760 1420757..1421188 - 432 WP_282929737.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QNH69_RS06765 1421225..1421419 - 195 WP_282929738.1 type II toxin-antitoxin system HicA family toxin Toxin
QNH69_RS06770 1421837..1423234 - 1398 WP_282929739.1 glycoside hydrolase family 32 protein -
QNH69_RS06775 1423234..1425162 - 1929 WP_282929740.1 sucrose-specific PTS transporter subunit IIBC -
QNH69_RS06780 1425223..1426173 - 951 WP_282929741.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1419887..1420360 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-63)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-108)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7072.32 Da        Isoelectric Point: 10.6845

>T296976 WP_282929738.1 NZ_OX458331:c1421419-1421225 [Anaerococcus sp. Marseille-Q7828]
MPMTSKQMIKFLKKNGFTYVPSGDGSHKKFKNFETGKVTIVPDHGGKDLPKGTEHVILKQAGLK

Download         Length: 195 bp

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16325.61 Da        Isoelectric Point: 4.3099

>AT296976 WP_282929737.1 NZ_OX458331:c1421188-1420757 [Anaerococcus sp. Marseille-Q7828]
MFVNYPALFLKEKDSDAFTVVFPDLQGCVTYGDSVNDALKMAQDALGAYLFEYYTKPNDIPKASSIDDIELKIDEEDKEY
FLYEGSFKNYVSLDLTDYVKKSSIKNVKKTLTIPSYLNEAGIENNINFSLLLQEALKKELKMI

Download         Length: 432 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References