Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4494253..4495067 Replicon chromosome
Accession NZ_OX442412
Organism Salmonella enterica subsp. enterica serovar Rissen isolate pure strain

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag QM550_RS21970 Protein ID WP_000971653.1
Coordinates 4494253..4494780 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag QM550_RS21975 Protein ID WP_000855694.1
Coordinates 4494777..4495067 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM550_RS21940 (4490554) 4490554..4490952 + 399 Protein_4282 cytoplasmic protein -
QM550_RS21945 (4491163) 4491163..4491381 + 219 Protein_4283 hypothetical protein -
QM550_RS21950 (4491538) 4491538..4492206 + 669 WP_023137848.1 hypothetical protein -
QM550_RS21955 (4492233) 4492233..4492727 + 495 WP_000424947.1 hypothetical protein -
QM550_RS21960 (4492972) 4492972..4493628 - 657 WP_000420449.1 protein-serine/threonine phosphatase -
QM550_RS21965 (4493978) 4493978..4494180 + 203 Protein_4287 IS5/IS1182 family transposase -
QM550_RS21970 (4494253) 4494253..4494780 - 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
QM550_RS21975 (4494777) 4494777..4495067 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
QM550_RS21980 (4495337) 4495337..4495537 - 201 Protein_4290 IS3 family transposase -
QM550_RS21985 (4495778) 4495778..4496104 + 327 WP_000393297.1 hypothetical protein -
QM550_RS21990 (4496376) 4496376..4496723 - 348 WP_001555786.1 DUF1493 family protein -
QM550_RS21995 (4496708) 4496708..4497157 - 450 WP_000381616.1 hypothetical protein -
QM550_RS22000 (4497576) 4497576..4498019 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
QM550_RS22005 (4498476) 4498476..4499126 + 651 WP_023166786.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 4494040..4504439 10399
- flank IS/Tn - - 4494040..4494180 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T296972 WP_000971653.1 NZ_OX442412:c4494780-4494253 [Salmonella enterica subsp. enterica serovar Rissen]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT296972 WP_000855694.1 NZ_OX442412:c4495067-4494777 [Salmonella enterica subsp. enterica serovar Rissen]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References