Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3543852..3544428 Replicon chromosome
Accession NZ_OX442412
Organism Salmonella enterica subsp. enterica serovar Rissen isolate pure strain

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag QM550_RS17425 Protein ID WP_001131963.1
Coordinates 3543852..3544139 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag QM550_RS17430 Protein ID WP_000063143.1
Coordinates 3544126..3544428 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM550_RS17415 (3538962) 3538962..3542471 - 3510 WP_023138516.1 type I restriction-modification system endonuclease -
QM550_RS17420 (3542669) 3542669..3543583 + 915 WP_023138517.1 restriction endonuclease -
QM550_RS17425 (3543852) 3543852..3544139 + 288 WP_001131963.1 BrnT family toxin Toxin
QM550_RS17430 (3544126) 3544126..3544428 + 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
QM550_RS17435 (3544503) 3544503..3545459 - 957 WP_000187840.1 GTPase -
QM550_RS17440 (3545470) 3545470..3545673 - 204 WP_000460616.1 YbdD/YjiX family protein -
QM550_RS17445 (3545768) 3545768..3547918 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T296970 WP_001131963.1 NZ_OX442412:3543852-3544139 [Salmonella enterica subsp. enterica serovar Rissen]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT296970 WP_000063143.1 NZ_OX442412:3544126-3544428 [Salmonella enterica subsp. enterica serovar Rissen]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References