Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2570226..2570986 Replicon chromosome
Accession NZ_OX442412
Organism Salmonella enterica subsp. enterica serovar Rissen isolate pure strain

Toxin (Protein)


Gene name tacT Uniprot ID A0A620G002
Locus tag QM550_RS12855 Protein ID WP_023138210.1
Coordinates 2570226..2570711 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag QM550_RS12860 Protein ID WP_000965889.1
Coordinates 2570699..2570986 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM550_RS12825 (2565288) 2565288..2565950 + 663 WP_000747548.1 OmpA family lipoprotein -
QM550_RS12830 (2566180) 2566180..2567154 + 975 WP_023138208.1 glyoxylate/hydroxypyruvate reductase GhrB -
QM550_RS12835 (2567204) 2567204..2567914 - 711 WP_023138209.1 DUF3053 domain-containing protein -
QM550_RS12840 (2568353) 2568353..2568643 + 291 WP_000455790.1 HTH-type transcriptional regulator -
QM550_RS12845 (2568931) 2568931..2569143 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
QM550_RS12850 (2569316) 2569316..2569855 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
QM550_RS12855 (2570226) 2570226..2570711 - 486 WP_023138210.1 GNAT family N-acetyltransferase Toxin
QM550_RS12860 (2570699) 2570699..2570986 - 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
QM550_RS12865 (2571198) 2571198..2571443 + 246 WP_023138211.1 hypothetical protein -
QM550_RS12870 (2571500) 2571500..2572123 + 624 WP_000082043.1 hypothetical protein -
QM550_RS12875 (2572364) 2572364..2572701 + 338 Protein_2521 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17643.31 Da        Isoelectric Point: 9.8719

>T296965 WP_023138210.1 NZ_OX442412:c2570711-2570226 [Salmonella enterica subsp. enterica serovar Rissen]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSSHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT296965 WP_000965889.1 NZ_OX442412:c2570986-2570699 [Salmonella enterica subsp. enterica serovar Rissen]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A620G002

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References