Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2005813..2006433 Replicon chromosome
Accession NZ_OX442412
Organism Salmonella enterica subsp. enterica serovar Rissen isolate pure strain

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QM550_RS10135 Protein ID WP_001280991.1
Coordinates 2006215..2006433 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QM550_RS10130 Protein ID WP_000344807.1
Coordinates 2005813..2006187 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM550_RS10120 (2000952) 2000952..2002145 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QM550_RS10125 (2002168) 2002168..2005317 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QM550_RS10130 (2005813) 2005813..2006187 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QM550_RS10135 (2006215) 2006215..2006433 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QM550_RS10140 (2006612) 2006612..2007163 + 552 WP_001278793.1 maltose O-acetyltransferase -
QM550_RS10145 (2007281) 2007281..2007751 + 471 WP_000136183.1 YlaC family protein -
QM550_RS10150 (2007806) 2007806..2007946 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QM550_RS10155 (2007952) 2007952..2008212 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
QM550_RS10160 (2008437) 2008437..2009987 + 1551 WP_000213144.1 EAL domain-containing protein -
QM550_RS10170 (2010218) 2010218..2010607 + 390 WP_000961285.1 MGMT family protein -
QM550_RS10175 (2010640) 2010640..2011209 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T296963 WP_001280991.1 NZ_OX442412:2006215-2006433 [Salmonella enterica subsp. enterica serovar Rissen]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT296963 WP_000344807.1 NZ_OX442412:2005813-2006187 [Salmonella enterica subsp. enterica serovar Rissen]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References