Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1403200..1404116 Replicon chromosome
Accession NZ_OX419652
Organism Bacillus subtilis isolate NRS6131

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag KJP56_RS07360 Protein ID WP_015715744.1
Coordinates 1403370..1404116 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP56_RS07355 Protein ID WP_003232646.1
Coordinates 1403200..1403370 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP56_RS07310 (1398432) 1398432..1399010 + 579 WP_015483131.1 YmfQ family protein -
KJP56_RS07315 (1399007) 1399007..1399279 + 273 WP_003232665.1 hypothetical protein -
KJP56_RS07320 (1399282) 1399282..1399611 + 330 Protein_1378 terminase -
KJP56_RS07325 (1400775) 1400775..1401236 + 462 WP_072174134.1 hypothetical protein -
KJP56_RS07330 (1401226) 1401226..1401417 + 192 WP_080375511.1 phage portal protein -
KJP56_RS07335 (1401489) 1401489..1401758 + 270 WP_072174140.1 hemolysin XhlA family protein -
KJP56_RS07340 (1401771) 1401771..1402034 + 264 WP_014479566.1 phage holin -
KJP56_RS07345 (1402047) 1402047..1402940 + 894 WP_163117447.1 N-acetylmuramoyl-L-alanine amidase -
KJP56_RS07350 (1402977) 1402977..1403114 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP56_RS07355 (1403200) 1403200..1403370 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP56_RS07360 (1403370) 1403370..1404116 - 747 WP_015715744.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP56_RS07365 (1404226) 1404226..1405227 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP56_RS07370 (1405240) 1405240..1405857 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP56_RS07375 (1406133) 1406133..1407449 - 1317 WP_128740275.1 serine/threonine exchanger -
KJP56_RS07380 (1407838) 1407838..1408788 + 951 WP_015252261.1 ring-cleaving dioxygenase -
KJP56_RS07385 (1408889) 1408889..1409036 + 148 Protein_1391 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29043.47 Da        Isoelectric Point: 4.6191

>T296950 WP_015715744.1 NZ_OX419652:c1404116-1403370 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHIYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296950 WP_003232646.1 NZ_OX419652:c1403370-1403200 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References