296914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1320227..1321143 Replicon chromosome
Accession NZ_OX419579
Organism Bacillus subtilis isolate NRS6103

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP43_RS06945 Protein ID WP_003244695.1
Coordinates 1320397..1321143 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP43_RS06940 Protein ID WP_003232646.1
Coordinates 1320227..1320397 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP43_RS06905 (1317093) 1317093..1317419 + 327 WP_029727046.1 XkdW family protein -
KJP43_RS06910 (1317416) 1317416..1317580 + 165 WP_014479563.1 XkdX family protein -
KJP43_RS06915 (1317624) 1317624..1318463 + 840 WP_029727045.1 phage-like element PBSX protein XepA -
KJP43_RS06920 (1318516) 1318516..1318785 + 270 WP_015252265.1 hemolysin XhlA family protein -
KJP43_RS06925 (1318798) 1318798..1319061 + 264 WP_014479566.1 phage holin -
KJP43_RS06930 (1319074) 1319074..1319967 + 894 WP_029727044.1 N-acetylmuramoyl-L-alanine amidase -
KJP43_RS06935 (1320004) 1320004..1320141 - 138 WP_119899277.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP43_RS06940 (1320227) 1320227..1320397 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP43_RS06945 (1320397) 1320397..1321143 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP43_RS06950 (1321253) 1321253..1322254 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP43_RS06955 (1322267) 1322267..1322884 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP43_RS06960 (1323160) 1323160..1324476 - 1317 WP_015252262.1 serine/threonine exchanger -
KJP43_RS06965 (1324864) 1324864..1325814 + 951 WP_003232637.1 VOC family protein -
KJP43_RS06970 (1325923) 1325923..1326018 + 96 Protein_1309 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296914 WP_003244695.1 NZ_OX419579:c1321143-1320397 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296914 WP_003232646.1 NZ_OX419579:c1320397-1320227 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References