Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1308137..1309053 Replicon chromosome
Accession NZ_OX419578
Organism Bacillus subtilis isolate NRS6128

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP45_RS06880 Protein ID WP_003244695.1
Coordinates 1308307..1309053 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP45_RS06875 Protein ID WP_003232646.1
Coordinates 1308137..1308307 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP45_RS06840 (NRS6128_06775) 1304997..1305326 + 330 WP_080529228.1 XkdW family protein -
KJP45_RS06845 (NRS6128_06780) 1305323..1305487 + 165 WP_047182493.1 XkdX family protein -
KJP45_RS06850 (NRS6128_06785) 1305534..1306373 + 840 WP_029317677.1 phage-like element PBSX protein XepA -
KJP45_RS06855 (NRS6128_06790) 1306426..1306695 + 270 WP_003232655.1 hemolysin XhlA family protein -
KJP45_RS06860 (NRS6128_06795) 1306708..1306971 + 264 WP_029317678.1 phage holin -
KJP45_RS06865 (NRS6128_06800) 1306984..1307877 + 894 WP_029317679.1 N-acetylmuramoyl-L-alanine amidase -
KJP45_RS06870 (NRS6128_06805) 1307914..1308051 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP45_RS06875 (NRS6128_06810) 1308137..1308307 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP45_RS06880 (NRS6128_06815) 1308307..1309053 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP45_RS06885 (NRS6128_06820) 1309163..1310164 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP45_RS06890 (NRS6128_06825) 1310177..1310794 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP45_RS06895 (NRS6128_06830) 1311070..1312386 - 1317 WP_080529229.1 serine/threonine exchanger -
KJP45_RS06900 (NRS6128_06835) 1312770..1313720 + 951 WP_213414432.1 ring-cleaving dioxygenase -
KJP45_RS06905 1313830..1313931 + 102 Protein_1296 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296912 WP_003244695.1 NZ_OX419578:c1309053-1308307 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296912 WP_003232646.1 NZ_OX419578:c1308307-1308137 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References