296901

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1342864..1343780 Replicon chromosome
Accession NZ_OX419577
Organism Bacillus subtilis isolate NRS6120

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP47_RS07030 Protein ID WP_003244695.1
Coordinates 1343034..1343780 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP47_RS07025 Protein ID WP_003232646.1
Coordinates 1342864..1343034 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP47_RS06990 (1339726) 1339726..1340055 + 330 WP_017695120.1 XkdW family protein -
KJP47_RS06995 (1340052) 1340052..1340216 + 165 WP_213383475.1 XkdX family protein -
KJP47_RS07000 (1340260) 1340260..1341099 + 840 WP_213383476.1 phage-like element PBSX protein XepA -
KJP47_RS07005 (1341152) 1341152..1341421 + 270 WP_015252265.1 hemolysin XhlA family protein -
KJP47_RS07010 (1341434) 1341434..1341697 + 264 WP_003232653.1 phage holin -
KJP47_RS07015 (1341710) 1341710..1342603 + 894 WP_014479567.1 N-acetylmuramoyl-L-alanine amidase -
KJP47_RS07020 (1342641) 1342641..1342778 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP47_RS07025 (1342864) 1342864..1343034 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP47_RS07030 (1343034) 1343034..1343780 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP47_RS07035 (1343889) 1343889..1344890 - 1002 WP_014479569.1 inorganic phosphate transporter -
KJP47_RS07040 (1344903) 1344903..1345520 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP47_RS07045 (1345796) 1345796..1347112 - 1317 WP_213383477.1 amino acid permease -
KJP47_RS07050 (1347501) 1347501..1348451 + 951 WP_213383478.1 ring-cleaving dioxygenase -
KJP47_RS07055 (1348551) 1348551..1348697 + 147 WP_121591715.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296901 WP_003244695.1 NZ_OX419577:c1343780-1343034 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296901 WP_003232646.1 NZ_OX419577:c1343034-1342864 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References