Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1329606..1330522 Replicon chromosome
Accession NZ_OX419575
Organism Bacillus subtilis isolate NRS6121

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP52_RS06980 Protein ID WP_003244695.1
Coordinates 1329776..1330522 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP52_RS06975 Protein ID WP_003232646.1
Coordinates 1329606..1329776 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP52_RS06940 (1326469) 1326469..1326798 + 330 WP_003232660.1 XkdW family protein -
KJP52_RS06945 (1326795) 1326795..1326959 + 165 WP_003232658.1 XkdX family protein -
KJP52_RS06950 (1327003) 1327003..1327842 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
KJP52_RS06955 (1327895) 1327895..1328164 + 270 WP_003232655.1 hemolysin XhlA family protein -
KJP52_RS06960 (1328177) 1328177..1328440 + 264 WP_003232653.1 phage holin -
KJP52_RS06965 (1328453) 1328453..1329346 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
KJP52_RS06970 (1329383) 1329383..1329520 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP52_RS06975 (1329606) 1329606..1329776 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP52_RS06980 (1329776) 1329776..1330522 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP52_RS06985 (1330632) 1330632..1331633 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP52_RS06990 (1331646) 1331646..1332263 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP52_RS06995 (1332539) 1332539..1333855 - 1317 WP_003244819.1 serine/threonine exchanger -
KJP52_RS07000 (1334244) 1334244..1335194 + 951 WP_003245086.1 ring-cleaving dioxygenase -
KJP52_RS07005 (1335295) 1335295..1335441 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296889 WP_003244695.1 NZ_OX419575:c1330522-1329776 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296889 WP_003232646.1 NZ_OX419575:c1329776-1329606 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References