296874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1369514..1370430 Replicon chromosome
Accession NZ_OX419573
Organism Bacillus subtilis isolate NRS6085

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP57_RS07285 Protein ID WP_003244695.1
Coordinates 1369684..1370430 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP57_RS07280 Protein ID WP_003232646.1
Coordinates 1369514..1369684 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP57_RS07245 (1366380) 1366380..1366706 + 327 WP_124059766.1 XkdW family protein -
KJP57_RS07250 (1366703) 1366703..1366867 + 165 WP_014479563.1 XkdX family protein -
KJP57_RS07255 (1366911) 1366911..1367750 + 840 WP_041850926.1 phage-like element PBSX protein XepA -
KJP57_RS07260 (1367803) 1367803..1368072 + 270 WP_003232655.1 hemolysin XhlA family protein -
KJP57_RS07265 (1368085) 1368085..1368348 + 264 WP_003232653.1 phage holin -
KJP57_RS07270 (1368361) 1368361..1369254 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
KJP57_RS07275 (1369291) 1369291..1369428 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP57_RS07280 (1369514) 1369514..1369684 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP57_RS07285 (1369684) 1369684..1370430 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP57_RS07290 (1370540) 1370540..1371541 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP57_RS07295 (1371554) 1371554..1372171 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP57_RS07300 (1372447) 1372447..1373763 - 1317 WP_128740275.1 serine/threonine exchanger -
KJP57_RS07305 (1374152) 1374152..1375102 + 951 WP_015252261.1 ring-cleaving dioxygenase -
KJP57_RS07310 (1375203) 1375203..1375349 + 147 WP_122894618.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296874 WP_003244695.1 NZ_OX419573:c1370430-1369684 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296874 WP_003232646.1 NZ_OX419573:c1369684-1369514 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References