Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1384796..1385712 Replicon chromosome
Accession NZ_OX419570
Organism Bacillus subtilis isolate NRS6134

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP59_RS07360 Protein ID WP_003244695.1
Coordinates 1384966..1385712 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP59_RS07355 Protein ID WP_003232646.1
Coordinates 1384796..1384966 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP59_RS07320 (1381659) 1381659..1381988 + 330 WP_003232660.1 XkdW family protein -
KJP59_RS07325 (1381985) 1381985..1382149 + 165 WP_003232658.1 XkdX family protein -
KJP59_RS07330 (1382193) 1382193..1383032 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
KJP59_RS07335 (1383085) 1383085..1383354 + 270 WP_003232655.1 hemolysin XhlA family protein -
KJP59_RS07340 (1383367) 1383367..1383630 + 264 WP_003232653.1 phage holin -
KJP59_RS07345 (1383643) 1383643..1384536 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
KJP59_RS07350 (1384573) 1384573..1384710 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP59_RS07355 (1384796) 1384796..1384966 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP59_RS07360 (1384966) 1384966..1385712 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP59_RS07365 (1385822) 1385822..1386823 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP59_RS07370 (1386836) 1386836..1387453 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP59_RS07375 (1387729) 1387729..1389045 - 1317 WP_063695059.1 serine/threonine exchanger -
KJP59_RS07380 (1389434) 1389434..1390384 + 951 WP_003245086.1 ring-cleaving dioxygenase -
KJP59_RS07385 (1390485) 1390485..1390631 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296866 WP_003244695.1 NZ_OX419570:c1385712-1384966 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296866 WP_003232646.1 NZ_OX419570:c1384966-1384796 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References