296845

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1348027..1348943 Replicon chromosome
Accession NZ_OX419569
Organism Bacillus subtilis isolate NRS6118

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP55_RS07100 Protein ID WP_003244695.1
Coordinates 1348197..1348943 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP55_RS07095 Protein ID WP_003232646.1
Coordinates 1348027..1348197 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP55_RS07060 (1344890) 1344890..1345219 + 330 WP_003232660.1 XkdW family protein -
KJP55_RS07065 (1345216) 1345216..1345380 + 165 WP_003232658.1 XkdX family protein -
KJP55_RS07070 (1345424) 1345424..1346263 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
KJP55_RS07075 (1346316) 1346316..1346585 + 270 WP_003232655.1 hemolysin XhlA family protein -
KJP55_RS07080 (1346598) 1346598..1346861 + 264 WP_003232653.1 phage holin -
KJP55_RS07085 (1346874) 1346874..1347767 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
KJP55_RS07090 (1347804) 1347804..1347941 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP55_RS07095 (1348027) 1348027..1348197 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP55_RS07100 (1348197) 1348197..1348943 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP55_RS07105 (1349053) 1349053..1350054 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP55_RS07110 (1350067) 1350067..1350684 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP55_RS07115 (1350960) 1350960..1352276 - 1317 WP_003244819.1 serine/threonine exchanger -
KJP55_RS07120 (1352665) 1352665..1353615 + 951 WP_003245086.1 ring-cleaving dioxygenase -
KJP55_RS07125 (1353716) 1353716..1353862 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296845 WP_003244695.1 NZ_OX419569:c1348943-1348197 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296845 WP_003232646.1 NZ_OX419569:c1348197-1348027 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References