296837

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1327529..1328445 Replicon chromosome
Accession NZ_OX419567
Organism Bacillus subtilis isolate NRS6107

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP42_RS06960 Protein ID WP_003244695.1
Coordinates 1327699..1328445 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP42_RS06955 Protein ID WP_003232646.1
Coordinates 1327529..1327699 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP42_RS06920 (1324392) 1324392..1324721 + 330 WP_003232660.1 XkdW family protein -
KJP42_RS06925 (1324718) 1324718..1324882 + 165 WP_003232658.1 XkdX family protein -
KJP42_RS06930 (1324926) 1324926..1325765 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
KJP42_RS06935 (1325818) 1325818..1326087 + 270 WP_003232655.1 hemolysin XhlA family protein -
KJP42_RS06940 (1326100) 1326100..1326363 + 264 WP_003232653.1 phage holin -
KJP42_RS06945 (1326376) 1326376..1327269 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
KJP42_RS06950 (1327306) 1327306..1327443 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP42_RS06955 (1327529) 1327529..1327699 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP42_RS06960 (1327699) 1327699..1328445 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP42_RS06965 (1328555) 1328555..1329556 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP42_RS06970 (1329569) 1329569..1330186 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP42_RS06975 (1330462) 1330462..1331778 - 1317 WP_003244819.1 serine/threonine exchanger -
KJP42_RS06980 (1332167) 1332167..1333117 + 951 WP_003245086.1 ring-cleaving dioxygenase -
KJP42_RS06985 (1333218) 1333218..1333364 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296837 WP_003244695.1 NZ_OX419567:c1328445-1327699 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296837 WP_003232646.1 NZ_OX419567:c1327699-1327529 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References