296833

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1319780..1320696 Replicon chromosome
Accession NZ_OX419565
Organism Bacillus subtilis isolate NRS6145

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP64_RS06940 Protein ID WP_003244695.1
Coordinates 1319950..1320696 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP64_RS06935 Protein ID WP_003232646.1
Coordinates 1319780..1319950 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP64_RS06900 (NRS6145_06815) 1316643..1316972 + 330 WP_003232660.1 XkdW family protein -
KJP64_RS06905 (NRS6145_06820) 1316969..1317133 + 165 WP_003232658.1 XkdX family protein -
KJP64_RS06910 (NRS6145_06825) 1317177..1318016 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
KJP64_RS06915 (NRS6145_06830) 1318069..1318338 + 270 WP_003232655.1 hemolysin XhlA family protein -
KJP64_RS06920 (NRS6145_06835) 1318351..1318614 + 264 WP_003232653.1 phage holin -
KJP64_RS06925 (NRS6145_06840) 1318627..1319520 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
KJP64_RS06930 1319557..1319694 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP64_RS06935 (NRS6145_06845) 1319780..1319950 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP64_RS06940 (NRS6145_06850) 1319950..1320696 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP64_RS06945 (NRS6145_06855) 1320806..1321807 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP64_RS06950 (NRS6145_06860) 1321820..1322437 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP64_RS06955 (NRS6145_06865) 1322713..1324029 - 1317 WP_003244819.1 serine/threonine exchanger -
KJP64_RS06960 (NRS6145_06870) 1324418..1325368 + 951 WP_003245086.1 ring-cleaving dioxygenase -
KJP64_RS06965 1325477..1325572 + 96 Protein_1311 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296833 WP_003244695.1 NZ_OX419565:c1320696-1319950 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296833 WP_003232646.1 NZ_OX419565:c1319950-1319780 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References