296818

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1320224..1321140 Replicon chromosome
Accession NZ_OX419564
Organism Bacillus subtilis isolate NRS6127

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP48_RS06940 Protein ID WP_003244695.1
Coordinates 1320394..1321140 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP48_RS06935 Protein ID WP_003232646.1
Coordinates 1320224..1320394 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP48_RS06900 (1317090) 1317090..1317416 + 327 WP_029727046.1 XkdW family protein -
KJP48_RS06905 (1317413) 1317413..1317577 + 165 WP_014479563.1 XkdX family protein -
KJP48_RS06910 (1317621) 1317621..1318460 + 840 WP_029727045.1 phage-like element PBSX protein XepA -
KJP48_RS06915 (1318513) 1318513..1318782 + 270 WP_015252265.1 hemolysin XhlA family protein -
KJP48_RS06920 (1318795) 1318795..1319058 + 264 WP_014479566.1 phage holin -
KJP48_RS06925 (1319071) 1319071..1319964 + 894 WP_029727044.1 N-acetylmuramoyl-L-alanine amidase -
KJP48_RS06930 (1320001) 1320001..1320138 - 138 WP_119899277.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP48_RS06935 (1320224) 1320224..1320394 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP48_RS06940 (1320394) 1320394..1321140 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP48_RS06945 (1321250) 1321250..1322251 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP48_RS06950 (1322264) 1322264..1322881 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP48_RS06955 (1323157) 1323157..1324473 - 1317 WP_015252262.1 serine/threonine exchanger -
KJP48_RS06960 (1324861) 1324861..1325811 + 951 WP_003232637.1 VOC family protein -
KJP48_RS06965 (1325920) 1325920..1326015 + 96 Protein_1308 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296818 WP_003244695.1 NZ_OX419564:c1321140-1320394 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296818 WP_003232646.1 NZ_OX419564:c1320394-1320224 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References