296810

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1402769..1403685 Replicon chromosome
Accession NZ_OX419563
Organism Bacillus subtilis isolate NRS6153

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP66_RS07485 Protein ID WP_003244695.1
Coordinates 1402939..1403685 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP66_RS07480 Protein ID WP_003232646.1
Coordinates 1402769..1402939 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP66_RS07445 (1399632) 1399632..1399961 + 330 WP_003232660.1 XkdW family protein -
KJP66_RS07450 (1399958) 1399958..1400122 + 165 WP_003232658.1 XkdX family protein -
KJP66_RS07455 (1400166) 1400166..1401005 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
KJP66_RS07460 (1401058) 1401058..1401327 + 270 WP_003232655.1 hemolysin XhlA family protein -
KJP66_RS07465 (1401340) 1401340..1401603 + 264 WP_003232653.1 phage holin -
KJP66_RS07470 (1401616) 1401616..1402509 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
KJP66_RS07475 (1402546) 1402546..1402683 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP66_RS07480 (1402769) 1402769..1402939 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP66_RS07485 (1402939) 1402939..1403685 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP66_RS07490 (1403795) 1403795..1404796 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP66_RS07495 (1404809) 1404809..1405426 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP66_RS07500 (1405702) 1405702..1407018 - 1317 WP_003244819.1 serine/threonine exchanger -
KJP66_RS07505 (1407407) 1407407..1408357 + 951 WP_003245086.1 ring-cleaving dioxygenase -
KJP66_RS07510 (1408458) 1408458..1408604 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296810 WP_003244695.1 NZ_OX419563:c1403685-1402939 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296810 WP_003232646.1 NZ_OX419563:c1402939-1402769 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References