296806

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1330122..1331038 Replicon chromosome
Accession NZ_OX419559
Organism Bacillus subtilis isolate NRS6099

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP68_RS06980 Protein ID WP_003244695.1
Coordinates 1330292..1331038 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP68_RS06975 Protein ID WP_003232646.1
Coordinates 1330122..1330292 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP68_RS06940 (NRS6099_06865) 1326988..1327314 + 327 WP_069703538.1 XkdW family protein -
KJP68_RS06945 (NRS6099_06870) 1327311..1327475 + 165 WP_014479563.1 XkdX family protein -
KJP68_RS06950 (NRS6099_06875) 1327519..1328358 + 840 WP_029727045.1 phage-like element PBSX protein XepA -
KJP68_RS06955 (NRS6099_06880) 1328411..1328680 + 270 WP_015252265.1 hemolysin XhlA family protein -
KJP68_RS06960 (NRS6099_06885) 1328693..1328956 + 264 WP_014479566.1 phage holin -
KJP68_RS06965 (NRS6099_06890) 1328969..1329862 + 894 WP_029727044.1 N-acetylmuramoyl-L-alanine amidase -
KJP68_RS06970 1329899..1330036 - 138 WP_119899277.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP68_RS06975 (NRS6099_06895) 1330122..1330292 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP68_RS06980 (NRS6099_06900) 1330292..1331038 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP68_RS06985 (NRS6099_06905) 1331148..1332149 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP68_RS06990 (NRS6099_06910) 1332162..1332779 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP68_RS06995 (NRS6099_06915) 1333055..1334371 - 1317 WP_029317680.1 serine/threonine exchanger -
KJP68_RS07000 (NRS6099_06920) 1334760..1335710 + 951 WP_014476561.1 ring-cleaving dioxygenase -
KJP68_RS07005 1335819..1335914 + 96 Protein_1316 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296806 WP_003244695.1 NZ_OX419559:c1331038-1330292 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296806 WP_003232646.1 NZ_OX419559:c1330292-1330122 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References