Detailed information of TA system TA029680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1638804..1639483
• Replicon: chromosome
• Accession: NC_021726
• Organism: Acinetobacter baumannii BJAB07104

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: BJAB07104_RS08025
• Protein ID: WP_000838146.1
• Coordinates: 1638804..1638986 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: BJAB07104_RS08030
• Protein ID: WP_000966688.1
• Coordinates: 1639079..1639483 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJAB07104_RS20255	1633911..1634081	+	171	WP_005119785.1	hypothetical protein	-
BJAB07104_RS07985	1634093..1634497	+	405	WP_020752395.1	hypothetical protein	-
BJAB07104_RS07990	1634469..1634837	+	369	WP_020752396.1	hypothetical protein	-
BJAB07104_RS07995	1634794..1635237	+	444	WP_073545229.1	hypothetical protein	-
BJAB07104_RS08000	1635239..1635457	+	219	WP_020752398.1	hypothetical protein	-
BJAB07104_RS08005	1635553..1635903	+	351	WP_020752399.1	hypothetical protein	-
BJAB07104_RS08010	1635903..1636886	+	984	WP_020752400.1	hypothetical protein	-
BJAB07104_RS08015	1636981..1637898	+	918	WP_020752401.1	hypothetical protein	-
BJAB07104_RS08020	1637969..1638478	+	510	WP_038338755.1	hypothetical protein	-
BJAB07104_RS08025	1638804..1638986	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
BJAB07104_RS08030	1639079..1639483	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BJAB07104_RS19650	1639582..1639758	+	177	WP_014466185.1	hypothetical protein	-
BJAB07104_RS08035	1639767..1640090	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
BJAB07104_RS08040	1640122..1640916	+	795	WP_000720608.1	hypothetical protein	-
BJAB07104_RS08045	1640965..1641204	-	240	WP_000763623.1	Arc family DNA-binding protein	-
BJAB07104_RS19655	1641327..1641482	+	156	WP_001103649.1	Arc family DNA-binding protein	-
BJAB07104_RS08050	1641479..1642471	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1600453..1659735	59282

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T29680 WP_000838146.1 NC_021726:1638804-1638986 [Acinetobacter baumannii BJAB07104]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T29680 NC_021726:1638804-1638986 [Acinetobacter baumannii BJAB07104]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT29680 WP_000966688.1 NC_021726:1639079-1639483 [Acinetobacter baumannii BJAB07104]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT29680 NC_021726:1639079-1639483 [Acinetobacter baumannii BJAB07104]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6