296763

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1322966..1323882 Replicon chromosome
Accession NZ_OX419553
Organism Bacillus subtilis isolate NRS6183

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP78_RS06955 Protein ID WP_003244695.1
Coordinates 1323136..1323882 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP78_RS06950 Protein ID WP_003232646.1
Coordinates 1322966..1323136 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP78_RS06915 (1319832) 1319832..1320158 + 327 WP_029727046.1 XkdW family protein -
KJP78_RS06920 (1320155) 1320155..1320319 + 165 WP_014479563.1 XkdX family protein -
KJP78_RS06925 (1320363) 1320363..1321202 + 840 WP_029727045.1 phage-like element PBSX protein XepA -
KJP78_RS06930 (1321255) 1321255..1321524 + 270 WP_015252265.1 hemolysin XhlA family protein -
KJP78_RS06935 (1321537) 1321537..1321800 + 264 WP_014479566.1 phage holin -
KJP78_RS06940 (1321813) 1321813..1322706 + 894 WP_029727044.1 N-acetylmuramoyl-L-alanine amidase -
KJP78_RS06945 (1322743) 1322743..1322880 - 138 WP_119899277.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP78_RS06950 (1322966) 1322966..1323136 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP78_RS06955 (1323136) 1323136..1323882 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP78_RS06960 (1323992) 1323992..1324993 - 1002 WP_014479569.1 inorganic phosphate transporter -
KJP78_RS06965 (1325006) 1325006..1325623 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP78_RS06970 (1325899) 1325899..1327215 - 1317 WP_015252262.1 serine/threonine exchanger -
KJP78_RS06975 (1327604) 1327604..1328554 + 951 WP_003245086.1 ring-cleaving dioxygenase -
KJP78_RS06980 (1328663) 1328663..1328758 + 96 Protein_1311 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296763 WP_003244695.1 NZ_OX419553:c1323882-1323136 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296763 WP_003232646.1 NZ_OX419553:c1323136-1322966 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References