296755

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1329642..1330558 Replicon chromosome
Accession NZ_OX419551
Organism Bacillus subtilis isolate NRS6190

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag KJP53_RS06970 Protein ID WP_003244695.1
Coordinates 1329812..1330558 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag KJP53_RS06965 Protein ID WP_003232646.1
Coordinates 1329642..1329812 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP53_RS06930 (1326505) 1326505..1326834 + 330 WP_003232660.1 XkdW family protein -
KJP53_RS06935 (1326831) 1326831..1326995 + 165 WP_003232658.1 XkdX family protein -
KJP53_RS06940 (1327039) 1327039..1327878 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
KJP53_RS06945 (1327931) 1327931..1328200 + 270 WP_003232655.1 hemolysin XhlA family protein -
KJP53_RS06950 (1328213) 1328213..1328476 + 264 WP_003232653.1 phage holin -
KJP53_RS06955 (1328489) 1328489..1329382 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
KJP53_RS06960 (1329419) 1329419..1329556 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
KJP53_RS06965 (1329642) 1329642..1329812 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
KJP53_RS06970 (1329812) 1329812..1330558 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
KJP53_RS06975 (1330668) 1330668..1331669 - 1002 WP_003232642.1 inorganic phosphate transporter -
KJP53_RS06980 (1331682) 1331682..1332299 - 618 WP_003218470.1 DUF47 domain-containing protein -
KJP53_RS06985 (1332575) 1332575..1333891 - 1317 WP_003244819.1 serine/threonine exchanger -
KJP53_RS06990 (1334280) 1334280..1335230 + 951 WP_003245086.1 ring-cleaving dioxygenase -
KJP53_RS06995 (1335331) 1335331..1335477 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T296755 WP_003244695.1 NZ_OX419551:c1330558-1329812 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT296755 WP_003232646.1 NZ_OX419551:c1329812-1329642 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References