Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 846851..847299 Replicon chromosome
Accession NZ_OX365700
Organism Nitrospira sp. DNF

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QWI75_RS04070 Protein ID WP_289267412.1
Coordinates 847066..847299 (+) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QWI75_RS04065 Protein ID WP_289267411.1
Coordinates 846851..847069 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QWI75_RS04050 (DNFV4_00845) 844020..845603 - 1584 WP_289267408.1 PAS domain S-box protein -
QWI75_RS04055 (DNFV4_00847) 846117..846308 + 192 WP_289267409.1 hypothetical protein -
QWI75_RS04060 846295..846681 - 387 WP_289267410.1 hypothetical protein -
QWI75_RS04065 (DNFV4_00849) 846851..847069 + 219 WP_289267411.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QWI75_RS04070 (DNFV4_00850) 847066..847299 + 234 WP_289267412.1 type II toxin-antitoxin system HicA family toxin Toxin
QWI75_RS04075 (DNFV4_00851) 847442..849388 - 1947 WP_289267413.1 TonB-dependent receptor -
QWI75_RS04080 (DNFV4_00852) 849920..850288 - 369 WP_289267414.1 hypothetical protein -
QWI75_RS04085 (DNFV4_00854) 850852..851811 - 960 WP_289267415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-67)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 9036.46 Da        Isoelectric Point: 10.0936

>T296741 WP_289267412.1 NZ_OX365700:847066-847299 [Nitrospira sp. DNF]
MTRLSIVDCKTMEKILLRLGFASVRQKGSHVFYRHPDGRTTTVPHHPSQDLARPLVREILREIDLTPEQFRRELDNL

Download         Length: 234 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8127.21 Da        Isoelectric Point: 4.3753

>AT296741 WP_289267411.1 NZ_OX365700:846851-847069 [Nitrospira sp. DNF]
MRTFAAYLEWDPDTQMYVGFVPGISGAHTQGKTLDELHKNLKEVLELCLEEYRASGEELPRFVGLQQIEVAG

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References