Detailed information of TA system TA296730

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pmenTA/darT(toxin)
• Location: 3370818..3372475
• Replicon: chromosome
• Accession: NZ_OX359235
• Organism: Alteromonas macleodii isolate Alteromonas macleodii BGP6

Toxin (Protein)

• Gene name: pmenT
• Uniprot ID: -
• Locus tag: EZ55_RS14595
• Protein ID: WP_231513104.1
• Coordinates: 3370818..3371411 (+)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: pmenA
• Uniprot ID: -
• Locus tag: EZ55_RS14600
• Protein ID: WP_061486365.1
• Coordinates: 3371411..3372475 (+)
• Length: 355 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EZ55_RS14580 (ALTBGP6_02953)	3366819..3368330	+	1512	WP_061486361.1	serine hydrolase domain-containing protein	-
EZ55_RS14585 (ALTBGP6_02954)	3368771..3369556	-	786	WP_061486362.1	BRO family protein	-
EZ55_RS14590 (ALTBGP6_02955)	3370187..3370762	+	576	WP_061486363.1	DarT ssDNA thymidine ADP-ribosyltransferase family protein	-
EZ55_RS14595 (ALTBGP6_02956)	3370818..3371411	+	594	WP_231513104.1	DUF4433 domain-containing protein	Toxin
EZ55_RS14600 (ALTBGP6_02957)	3371411..3372475	+	1065	WP_061486365.1	macro domain-containing protein	Antitoxin
EZ55_RS14605 (ALTBGP6_02958)	3372837..3375734	-	2898	WP_156079132.1	aminomethyl-transferring glycine dehydrogenase	-
EZ55_RS14610 (ALTBGP6_02959)	3375856..3376245	-	390	WP_014950360.1	glycine cleavage system protein GcvH	-
EZ55_RS14615 (ALTBGP6_02960)	3376297..3377376	-	1080	WP_156078713.1	glycine cleavage system aminomethyltransferase GcvT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ssDNA thymidine ADP-ribosyltransferase, DarT (1-197)

Antitoxin

• Macro domain (18-128)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 22882.97 Da
• Isoelectric Point: 6.9648

>T296730 WP_231513104.1 NZ_OX359235:3370818-3371411 [Alteromonas macleodii]
VHRNNIPWILDNGLYCGNSHVQSPNWEAIGNSELIQKRATHPVPISPFGSLNDYVPFYFTPFSPMLLNIKSGRGVKQRAN
EDIVILVSSLHKVEQLNLDFVYTDMHAYYQWASFYSDLNHLGEVDWPILQTRNFARDLNDPAKFERYQAEALVKQHCPIN
ALVGIACYNTRVEQELKHHIQQRNMNLDVIVRPGWYF

Nucleotide

• Length: 594 bp

Antitoxin

Protein

• Length: 355 a.a.
• Molecular weight: 40015.25 Da
• Isoelectric Point: 8.0792

>AT296730 WP_061486365.1 NZ_OX359235:3371411-3372475 [Alteromonas macleodii]
MITYTQGNLLEAQVEALVNTVNTVGVMGKGIALMFKERFPKNMAEYASACKAKQVNTGKMFVTETSELMGPKWIVNFPTK
QHWRAKSKMEWIQEGLIDLRYFLENNNVRSIAIPPLGAGQGGLAWPDVKMEIEKALSDIKTTNIIVFEPTSKYQNVAKAS
GVKKLTPARALVAELVRRYWILGMECSLLEIQKLAWFLQRTIEKRGLKNELKLKFEANYYGPYANNLDHLLNALDGSYLK
SDKRIPDCDPLDVIWFNESEKQKISTYLNTEAKEYLPALEGATQVISGFESPFGLELLSTVDWLVTNQGCERTVESIKEG
IANWPAGAKWAQRKFNLFSNKDIEFALTNLEILA

Nucleotide

• Length: 1065 bp