Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5049640..5051228 Replicon chromosome
Accession NZ_OX359182
Organism Klebsiella pneumoniae strain KP34 isolate 2018-347802-001-01

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag OM989_RS24240 Protein ID WP_004892016.1
Coordinates 5049906..5051228 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OM989_RS24235 Protein ID WP_004176198.1
Coordinates 5049640..5049906 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM989_RS24210 (5044669) 5044669..5045592 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
OM989_RS24215 (5045573) 5045573..5046727 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OM989_RS24220 (5047073) 5047073..5048452 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OM989_RS24225 (5048430) 5048430..5048930 + 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OM989_RS24230 (5048927) 5048927..5049253 + 327 WP_004184023.1 hydroxyisourate hydrolase -
OM989_RS24235 (5049640) 5049640..5049906 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OM989_RS24240 (5049906) 5049906..5051228 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
OM989_RS24245 (5051245) 5051245..5052537 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OM989_RS24250 (5052679) 5052679..5053683 - 1005 WP_032435338.1 fimbrial protein -
OM989_RS24255 (5053671) 5053671..5056172 - 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T296726 WP_004892016.1 NZ_OX359182:5049906-5051228 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT296726 WP_004176198.1 NZ_OX359182:5049640-5049906 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References