Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3005138..3005654 Replicon chromosome
Accession NZ_OX359182
Organism Klebsiella pneumoniae strain KP34 isolate 2018-347802-001-01

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OM989_RS14570 Protein ID WP_004178374.1
Coordinates 3005370..3005654 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag OM989_RS14565 Protein ID WP_032434351.1
Coordinates 3005138..3005380 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM989_RS14550 (3001167) 3001167..3001907 + 741 WP_002886899.1 KDGP aldolase family protein -
OM989_RS14555 (3001973) 3001973..3003127 + 1155 WP_002886900.1 lactonase family protein -
OM989_RS14560 (3003150) 3003150..3005060 + 1911 WP_004152270.1 PRD domain-containing protein -
OM989_RS14565 (3005138) 3005138..3005380 + 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OM989_RS14570 (3005370) 3005370..3005654 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM989_RS14575 (3005658) 3005658..3006122 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OM989_RS14580 (3006364) 3006364..3008502 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OM989_RS14585 (3008859) 3008859..3009602 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OM989_RS14590 (3009605) 3009605..3009778 - 174 WP_032414379.1 hypothetical protein -
OM989_RS14595 (3009863) 3009863..3010171 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T296722 WP_004178374.1 NZ_OX359182:3005370-3005654 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT296722 WP_032434351.1 NZ_OX359182:3005138-3005380 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References