Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1486338..1486995 Replicon chromosome
Accession NZ_OX359182
Organism Klebsiella pneumoniae strain KP34 isolate 2018-347802-001-01

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OM989_RS07090 Protein ID WP_002916310.1
Coordinates 1486338..1486748 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OM989_RS07095 Protein ID WP_002916312.1
Coordinates 1486729..1486995 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM989_RS07070 (1482338) 1482338..1484071 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
OM989_RS07075 (1484077) 1484077..1484790 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OM989_RS07080 (1484813) 1484813..1485709 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OM989_RS07085 (1485810) 1485810..1486331 + 522 WP_002916308.1 flavodoxin FldB -
OM989_RS07090 (1486338) 1486338..1486748 - 411 WP_002916310.1 protein YgfX Toxin
OM989_RS07095 (1486729) 1486729..1486995 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OM989_RS07100 (1487241) 1487241..1488224 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
OM989_RS07105 (1488323) 1488323..1488982 - 660 WP_004174454.1 hemolysin III family protein -
OM989_RS07110 (1489146) 1489146..1489457 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OM989_RS07115 (1489507) 1489507..1490235 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OM989_RS07120 (1490354) 1490354..1491787 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T296714 WP_002916310.1 NZ_OX359182:c1486748-1486338 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT296714 WP_002916312.1 NZ_OX359182:c1486995-1486729 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References