Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4849505..4850021 Replicon chromosome
Accession NZ_OX359175
Organism Klebsiella pneumoniae strain KP47 isolate 2018-047100-007-01

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag ONI05_RS23440 Protein ID WP_004178374.1
Coordinates 4849505..4849789 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag ONI05_RS23445 Protein ID WP_032434351.1
Coordinates 4849779..4850021 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONI05_RS23415 (4844988) 4844988..4845251 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
ONI05_RS23420 (4845381) 4845381..4845554 + 174 WP_032414379.1 hypothetical protein -
ONI05_RS23425 (4845557) 4845557..4846300 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
ONI05_RS23430 (4846657) 4846657..4848795 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
ONI05_RS23435 (4849037) 4849037..4849501 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ONI05_RS23440 (4849505) 4849505..4849789 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONI05_RS23445 (4849779) 4849779..4850021 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ONI05_RS23450 (4850099) 4850099..4852009 - 1911 WP_004152270.1 PRD domain-containing protein -
ONI05_RS23455 (4852032) 4852032..4853186 - 1155 WP_002886900.1 lactonase family protein -
ONI05_RS23460 (4853252) 4853252..4853992 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T296705 WP_004178374.1 NZ_OX359175:c4849789-4849505 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT296705 WP_032434351.1 NZ_OX359175:c4850021-4849779 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References