Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2758953..2760541 Replicon chromosome
Accession NZ_OX359175
Organism Klebsiella pneumoniae strain KP47 isolate 2018-047100-007-01

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag ONI05_RS13525 Protein ID WP_004892016.1
Coordinates 2758953..2760275 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ONI05_RS13530 Protein ID WP_004176198.1
Coordinates 2760275..2760541 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONI05_RS13510 (2754009) 2754009..2756510 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
ONI05_RS13515 (2756498) 2756498..2757502 + 1005 WP_032435338.1 fimbrial protein -
ONI05_RS13520 (2757644) 2757644..2758936 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
ONI05_RS13525 (2758953) 2758953..2760275 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
ONI05_RS13530 (2760275) 2760275..2760541 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ONI05_RS13535 (2760928) 2760928..2761254 - 327 WP_004184023.1 hydroxyisourate hydrolase -
ONI05_RS13540 (2761251) 2761251..2761751 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
ONI05_RS13545 (2761729) 2761729..2763108 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
ONI05_RS13550 (2763454) 2763454..2764608 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
ONI05_RS13555 (2764589) 2764589..2765512 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T296701 WP_004892016.1 NZ_OX359175:c2760275-2758953 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT296701 WP_004176198.1 NZ_OX359175:c2760541-2760275 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References