Detailed information of TA system TA296685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 799807..801059
• Replicon: chromosome
• Accession: NZ_OX352996
• Organism: Streptococcus suis isolate 861160_dhsdS

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: QNH80_RS03850
• Protein ID: WP_024405541.1
• Coordinates: 799807..800583 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: QNH80_RS03855
• Protein ID: WP_024405542.1
• Coordinates: 800583..801059 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QNH80_RS03840	795949..797763	-	1815	WP_024405539.1	ATP-dependent helicase	-
QNH80_RS03845	797750..799810	-	2061	WP_074400615.1	AAA family ATPase	-
QNH80_RS03850	799807..800583	-	777	WP_024405541.1	type II toxin-antitoxin system toxin PezT	Toxin
QNH80_RS03855	800583..801059	-	477	WP_024405542.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
QNH80_RS03860	801129..801419	-	291	WP_024405543.1	hypothetical protein	-
QNH80_RS03865	801469..801858	-	390	WP_024405544.1	DUF5945 family protein	-
QNH80_RS03870	801855..802082	-	228	WP_024418314.1	DUF5965 family protein	-
QNH80_RS03875	802136..803212	-	1077	WP_074400614.1	toprim domain-containing protein	-
QNH80_RS03880	803252..803890	-	639	WP_074400613.1	peptidylprolyl isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	neuB	738527..868148	129621

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29222.90 Da
• Isoelectric Point: 5.6995

>T296685 WP_024405541.1 NZ_OX352996:c800583-799807 [Streptococcus suis]
MRLEEFSEEEFQKALQRTIRAQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18303.70 Da
• Isoelectric Point: 4.3241

>AT296685 WP_024405542.1 NZ_OX352996:c801059-800583 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHWVVA

Nucleotide

• Length: 477 bp