Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 532348..532849 Replicon chromosome
Accession NZ_OX352996
Organism Streptococcus suis isolate 861160_dhsdS

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag QNH80_RS02595 Protein ID WP_024405694.1
Coordinates 532583..532849 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag QNH80_RS02590 Protein ID WP_012775104.1
Coordinates 532348..532599 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH80_RS02565 528267..528740 + 474 WP_024378560.1 IS200/IS605 family transposase -
QNH80_RS02570 528982..529122 + 141 WP_012775106.1 hypothetical protein -
QNH80_RS02575 529135..529512 + 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
QNH80_RS02580 529533..530285 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
QNH80_RS02585 530286..532256 + 1971 WP_024405693.1 FtsX-like permease family protein -
QNH80_RS02590 532348..532599 + 252 WP_012775104.1 DUF6290 family protein Antitoxin
QNH80_RS02595 532583..532849 + 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNH80_RS02600 532891..533556 + 666 WP_024405695.1 response regulator transcription factor -
QNH80_RS02605 533553..534494 + 942 WP_024405696.1 sensor histidine kinase -
QNH80_RS02610 534569..536077 + 1509 WP_024405697.1 phosphoglucomutase -
QNH80_RS02615 536147..537217 - 1071 WP_024405698.1 tyrosine recombinase XerS -
QNH80_RS02620 537384..537620 - 237 WP_226319150.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 528267..528740 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T296683 WP_024405694.1 NZ_OX352996:532583-532849 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT296683 WP_012775104.1 NZ_OX352996:532348-532599 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References