Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 950569..951070 Replicon chromosome
Accession NZ_OX352944
Organism Streptococcus suis isolate 861160_LM_H

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag QNH68_RS04585 Protein ID WP_024405694.1
Coordinates 950569..950835 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag QNH68_RS04590 Protein ID WP_012775104.1
Coordinates 950819..951070 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH68_RS04560 945798..946034 + 237 WP_226319150.1 hypothetical protein -
QNH68_RS04565 946201..947271 + 1071 WP_024405698.1 tyrosine recombinase XerS -
QNH68_RS04570 947341..948849 - 1509 WP_024405697.1 phosphoglucomutase -
QNH68_RS04575 948924..949865 - 942 WP_024405696.1 sensor histidine kinase -
QNH68_RS04580 949862..950527 - 666 WP_024405695.1 response regulator transcription factor -
QNH68_RS04585 950569..950835 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNH68_RS04590 950819..951070 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
QNH68_RS04595 951162..953132 - 1971 WP_024405693.1 FtsX-like permease family protein -
QNH68_RS04600 953133..953885 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
QNH68_RS04605 953906..954283 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
QNH68_RS04610 954296..954436 - 141 WP_012775106.1 hypothetical protein -
QNH68_RS04615 954678..955151 - 474 WP_024378560.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 954678..955151 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T296680 WP_024405694.1 NZ_OX352944:c950835-950569 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T296680 NZ_OX352944:c950835-950569 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACCTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGCATTGAAGATGACAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT296680 WP_012775104.1 NZ_OX352944:c951070-950819 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT296680 NZ_OX352944:c951070-950819 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References