Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 712724..713210 Replicon chromosome
Accession NZ_OX352944
Organism Streptococcus suis isolate 861160_LM_H

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag QNH68_RS03465 Protein ID WP_011922754.1
Coordinates 712941..713210 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag QNH68_RS03460 Protein ID WP_002938604.1
Coordinates 712724..712951 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH68_RS03435 708057..708602 - 546 WP_002941732.1 NADPH-dependent FMN reductase -
QNH68_RS03440 708665..709114 - 450 WP_024383028.1 MarR family transcriptional regulator -
QNH68_RS03445 709416..709913 + 498 WP_024405519.1 DUF5590 domain-containing protein -
QNH68_RS03450 709910..711091 + 1182 WP_024383693.1 pyridoxal phosphate-dependent aminotransferase -
QNH68_RS03455 711106..712452 + 1347 WP_024405517.1 asparagine--tRNA ligase -
QNH68_RS03460 712724..712951 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
QNH68_RS03465 712941..713210 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNH68_RS03470 713616..714940 + 1325 Protein_667 MATE family efflux transporter -
QNH68_RS03475 715124..715501 + 378 WP_002937263.1 RidA family protein -
QNH68_RS03480 715523..716410 + 888 WP_074390194.1 RNase adapter RapZ -
QNH68_RS03485 716407..717381 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T296679 WP_011922754.1 NZ_OX352944:712941-713210 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT296679 WP_002938604.1 NZ_OX352944:712724-712951 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References