Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 682364..683616 Replicon chromosome
Accession NZ_OX352944
Organism Streptococcus suis isolate 861160_LM_H

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag QNH68_RS03330 Protein ID WP_024405541.1
Coordinates 682840..683616 (+) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag QNH68_RS03325 Protein ID WP_024405542.1
Coordinates 682364..682840 (+) Length 159 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH68_RS03300 679533..680171 + 639 WP_074400613.1 peptidylprolyl isomerase -
QNH68_RS03305 680211..681287 + 1077 WP_074400614.1 toprim domain-containing protein -
QNH68_RS03310 681341..681568 + 228 WP_024418314.1 DUF5965 family protein -
QNH68_RS03315 681565..681954 + 390 WP_024405544.1 DUF5945 family protein -
QNH68_RS03320 682004..682294 + 291 WP_024405543.1 hypothetical protein -
QNH68_RS03325 682364..682840 + 477 WP_024405542.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
QNH68_RS03330 682840..683616 + 777 WP_024405541.1 type II toxin-antitoxin system toxin PezT Toxin
QNH68_RS03335 683613..685673 + 2061 WP_074400615.1 AAA family ATPase -
QNH68_RS03340 685660..687474 + 1815 WP_024405539.1 ATP-dependent helicase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - neuB 595772..699630 103858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-215)

Antitoxin

(3-60)


Sequences


Toxin        


Download         Length: 259 a.a.        Molecular weight: 29222.90 Da        Isoelectric Point: 5.6995

>T296678 WP_024405541.1 NZ_OX352944:682840-683616 [Streptococcus suis]
MRLEEFSEEEFQKALQRTIRAQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK

Download         Length: 777 bp


Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18303.70 Da        Isoelectric Point: 4.3241

>AT296678 WP_024405542.1 NZ_OX352944:682364-682840 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHWVVA

Download         Length: 477 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References