Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 653505..654937 Replicon chromosome
Accession NZ_OX352944
Organism Streptococcus suis isolate 861160_LM_H

Toxin (Protein)


Gene name abiEi Uniprot ID -
Locus tag QNH68_RS03220 Protein ID WP_074390209.1
Coordinates 653505..654350 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID Q8DZ36
Locus tag QNH68_RS03225 Protein ID WP_000037239.1
Coordinates 654347..654937 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH68_RS03215 650641..653442 + 2802 WP_074400605.1 phage tail tip lysozyme -
QNH68_RS03220 653505..654350 - 846 WP_074390209.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QNH68_RS03225 654347..654937 - 591 WP_000037239.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - neuB 595772..699630 103858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32524.20 Da        Isoelectric Point: 5.2246

>T296677 WP_074390209.1 NZ_OX352944:c654350-653505 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRFITVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23074.63 Da        Isoelectric Point: 7.8056

>AT296677 WP_000037239.1 NZ_OX352944:c654937-654347 [Streptococcus suis]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6Y8Q
AlphaFold DB A0A2I7ZET8

References