Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 703023..703524 Replicon chromosome
Accession NZ_OX352941
Organism Streptococcus suis isolate 861160_WT

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag QNH71_RS03465 Protein ID WP_024405694.1
Coordinates 703023..703289 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag QNH71_RS03470 Protein ID WP_012775104.1
Coordinates 703273..703524 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH71_RS03440 698252..698488 + 237 WP_226319150.1 hypothetical protein -
QNH71_RS03445 698655..699725 + 1071 WP_024405698.1 tyrosine recombinase XerS -
QNH71_RS03450 699795..701303 - 1509 WP_024405697.1 phosphoglucomutase -
QNH71_RS03455 701378..702319 - 942 WP_024405696.1 sensor histidine kinase -
QNH71_RS03460 702316..702981 - 666 WP_024405695.1 response regulator transcription factor -
QNH71_RS03465 703023..703289 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNH71_RS03470 703273..703524 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
QNH71_RS03475 703616..705586 - 1971 WP_024405693.1 FtsX-like permease family protein -
QNH71_RS03480 705587..706339 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
QNH71_RS03485 706360..706737 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
QNH71_RS03490 706750..706890 - 141 WP_012775106.1 hypothetical protein -
QNH71_RS03495 707132..707605 - 474 WP_024378560.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 707132..707605 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T296672 WP_024405694.1 NZ_OX352941:c703289-703023 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT296672 WP_012775104.1 NZ_OX352941:c703524-703273 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References