Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 799803..801055 Replicon chromosome
Accession NZ_OX352940
Organism Streptococcus suis isolate 861160_LM_A

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag QNH65_RS03850 Protein ID WP_024405541.1
Coordinates 799803..800579 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag QNH65_RS03855 Protein ID WP_024405542.1
Coordinates 800579..801055 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH65_RS03840 795945..797759 - 1815 WP_024405539.1 ATP-dependent helicase -
QNH65_RS03845 797746..799806 - 2061 WP_074400615.1 AAA family ATPase -
QNH65_RS03850 799803..800579 - 777 WP_024405541.1 type II toxin-antitoxin system toxin PezT Toxin
QNH65_RS03855 800579..801055 - 477 WP_024405542.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
QNH65_RS03860 801125..801415 - 291 WP_024405543.1 hypothetical protein -
QNH65_RS03865 801465..801854 - 390 WP_024405544.1 DUF5945 family protein -
QNH65_RS03870 801851..802078 - 228 WP_024418314.1 DUF5965 family protein -
QNH65_RS03875 802132..803208 - 1077 WP_074400614.1 toprim domain-containing protein -
QNH65_RS03880 803248..803886 - 639 WP_074400613.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - neuB 738523..868144 129621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29222.90 Da        Isoelectric Point: 5.6995

>T296661 WP_024405541.1 NZ_OX352940:c800579-799803 [Streptococcus suis]
MRLEEFSEEEFQKALQRTIRAQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK

Download         Length: 777 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18303.70 Da        Isoelectric Point: 4.3241

>AT296661 WP_024405542.1 NZ_OX352940:c801055-800579 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHWVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References