29666

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 2249969..2250540 Replicon chromosome
Accession NC_021717
Organism Alteromonas macleodii str. Ionian Sea U7

Toxin (Protein)


Gene name doc Uniprot ID A0A1E7D7Q9
Locus tag I876_RS09745 Protein ID WP_020745884.1
Coordinates 2250139..2250540 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1E7D7T8
Locus tag I876_RS09740 Protein ID WP_020745882.1
Coordinates 2249969..2250139 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I876_RS09720 2245216..2245881 - 666 WP_020743599.1 hypothetical protein -
I876_RS19850 2246240..2247755 + 1516 Protein_1909 transposase -
I876_RS09730 2248055..2249431 - 1377 WP_013785790.1 MBL fold metallo-hydrolase -
I876_RS09740 2249969..2250139 + 171 WP_020745882.1 hypothetical protein Antitoxin
I876_RS09745 2250139..2250540 + 402 WP_020745884.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I876_RS09750 2250753..2251352 + 600 WP_201765959.1 tyrosine-type recombinase/integrase -
I876_RS09755 2251437..2251862 - 426 WP_020745888.1 tyrosine-type recombinase/integrase -
I876_RS09760 2252135..2252494 - 360 Protein_1915 site-specific integrase -
I876_RS09765 2252871..2253326 - 456 WP_012518410.1 PaaI family thioesterase -
I876_RS20190 2253354..2253578 - 225 WP_012518411.1 GNAT family N-acetyltransferase -
I876_RS09775 2253822..2254253 - 432 Protein_1918 IS5/IS1182 family transposase -
I876_RS09780 2254428..2255435 - 1008 WP_020745894.1 zinc-dependent alcohol dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2253822..2254289 467


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(9-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14660.58 Da        Isoelectric Point: 3.9870

>T29666 WP_020745884.1 NC_021717:2250139-2250540 [Alteromonas mediterranea U7]
MELIFFPFERVIEINAYILENEPGMKGAADINKLQGALGRIDNAIVYLGLNDVFEIAAKYASSIALSHSLPDANKRTGLA
VALEYLSLNDYELIADNELFADAIRDLVVGKIGEADFADLLYAQYISEQNQNS

Download         Length: 402 bp

>T29666 NC_021717:2250139-2250540 [Alteromonas mediterranea U7]
ATGGAGCTTATTTTTTTCCCCTTCGAGCGCGTTATAGAGATTAACGCCTACATTCTCGAAAACGAGCCTGGTATGAAGGG
GGCCGCTGATATCAATAAGCTTCAGGGGGCGCTAGGCAGGATTGATAATGCTATTGTTTATTTAGGCTTGAATGATGTTT
TCGAAATAGCAGCAAAGTATGCTTCCTCTATTGCACTTTCTCATTCGCTTCCTGATGCAAACAAACGGACTGGTCTCGCT
GTAGCTTTGGAATATTTATCTCTCAATGATTATGAATTAATTGCTGATAACGAATTATTCGCAGATGCCATCAGAGATTT
GGTTGTGGGCAAAATTGGTGAAGCGGATTTTGCTGACCTTCTTTATGCTCAGTATATTTCTGAACAAAATCAAAATAGTT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6490.72 Da        Isoelectric Point: 10.9273

>AT29666 WP_020745882.1 NC_021717:2249969-2250139 [Alteromonas mediterranea U7]
MNTKIEVYGVKAVQRPKVPARKKLDLSGEFGQQIVKSETKLVLRTHKRTFEKLAYM

Download         Length: 171 bp

>AT29666 NC_021717:2249969-2250139 [Alteromonas mediterranea U7]
ATGAATACAAAAATTGAAGTTTACGGTGTTAAAGCTGTTCAACGCCCCAAAGTTCCAGCAAGAAAGAAACTTGACCTCTC
TGGTGAGTTTGGGCAACAGATCGTGAAATCCGAAACTAAGCTAGTGCTAAGAACACACAAGCGTACGTTCGAAAAACTCG
CTTACATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7D7Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7D7T8

References