Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 532349..532850 Replicon chromosome
Accession NZ_OX352940
Organism Streptococcus suis isolate 861160_LM_A

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag QNH65_RS02595 Protein ID WP_024405694.1
Coordinates 532584..532850 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag QNH65_RS02590 Protein ID WP_012775104.1
Coordinates 532349..532600 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH65_RS02565 528268..528741 + 474 WP_024378560.1 IS200/IS605 family transposase -
QNH65_RS02570 528983..529123 + 141 WP_012775106.1 hypothetical protein -
QNH65_RS02575 529136..529513 + 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
QNH65_RS02580 529534..530286 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
QNH65_RS02585 530287..532257 + 1971 WP_024405693.1 FtsX-like permease family protein -
QNH65_RS02590 532349..532600 + 252 WP_012775104.1 DUF6290 family protein Antitoxin
QNH65_RS02595 532584..532850 + 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNH65_RS02600 532892..533557 + 666 WP_024405695.1 response regulator transcription factor -
QNH65_RS02605 533554..534495 + 942 WP_024405696.1 sensor histidine kinase -
QNH65_RS02610 534570..536078 + 1509 WP_024405697.1 phosphoglucomutase -
QNH65_RS02615 536148..537218 - 1071 WP_024405698.1 tyrosine recombinase XerS -
QNH65_RS02620 537385..537621 - 237 WP_226319150.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 528268..528741 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T296659 WP_024405694.1 NZ_OX352940:532584-532850 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT296659 WP_012775104.1 NZ_OX352940:532349-532600 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References