Detailed information of TA system TA296646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 769080..770332
• Replicon: chromosome
• Accession: NZ_OX352806
• Organism: Streptococcus suis isolate 861160_dxerD_hsdSA

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: QNH74_RS03885
• Protein ID: WP_024405541.1
• Coordinates: 769556..770332 (+)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: QNH74_RS03880
• Protein ID: WP_024405542.1
• Coordinates: 769080..769556 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QNH74_RS03855	766249..766887	+	639	WP_074400613.1	peptidylprolyl isomerase	-
QNH74_RS03860	766927..768003	+	1077	WP_074400614.1	toprim domain-containing protein	-
QNH74_RS03865	768057..768284	+	228	WP_024418314.1	DUF5965 family protein	-
QNH74_RS03870	768281..768670	+	390	WP_024405544.1	DUF5945 family protein	-
QNH74_RS03875	768720..769010	+	291	WP_024405543.1	hypothetical protein	-
QNH74_RS03880	769080..769556	+	477	WP_024405542.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
QNH74_RS03885	769556..770332	+	777	WP_024405541.1	type II toxin-antitoxin system toxin PezT	Toxin
QNH74_RS03890	770329..772389	+	2061	WP_074400615.1	AAA family ATPase	-
QNH74_RS03895	772376..774190	+	1815	WP_024405539.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	neuB	682488..786346	103858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29222.90 Da
• Isoelectric Point: 5.6995

>T296646 WP_024405541.1 NZ_OX352806:769556-770332 [Streptococcus suis]
MRLEEFSEEEFQKALQRTIRAQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18303.70 Da
• Isoelectric Point: 4.3241

>AT296646 WP_024405542.1 NZ_OX352806:769080-769556 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHWVVA

Nucleotide

• Length: 477 bp