296644

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 572245..572728 Replicon chromosome
Accession NZ_OX352806
Organism Streptococcus suis isolate 861160_dxerD_hsdSA

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag QNH74_RS02965 Protein ID WP_012027435.1
Coordinates 572468..572728 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag QNH74_RS02960 Protein ID WP_012775256.1
Coordinates 572245..572466 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH74_RS02920 567468..567650 + 183 WP_024405996.1 hypothetical protein -
QNH74_RS02925 567742..568353 + 612 WP_024405995.1 hypothetical protein -
QNH74_RS02930 568400..568828 + 429 WP_074389766.1 replication protein -
QNH74_RS02935 568836..569147 + 312 WP_024405994.1 hypothetical protein -
QNH74_RS02940 569165..569578 + 414 WP_024405993.1 hypothetical protein -
QNH74_RS02945 570318..570500 + 183 WP_015647112.1 type II toxin-antitoxin system HicA family toxin -
QNH74_RS02950 570540..570992 + 453 WP_074389768.1 type II toxin-antitoxin system HicB family antitoxin -
QNH74_RS02955 571106..571315 + 210 WP_015647110.1 hypothetical protein -
QNH74_RS02960 572245..572466 + 222 WP_012775256.1 DUF6290 family protein Antitoxin
QNH74_RS02965 572468..572728 + 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNH74_RS02970 572895..573536 + 642 WP_023370899.1 HAD family hydrolase -
QNH74_RS02975 573569..573754 - 186 WP_002935693.1 hypothetical protein -
QNH74_RS02980 573818..574822 - 1005 WP_023370897.1 lactonase family protein -
QNH74_RS02985 574958..576124 + 1167 WP_012775254.1 AI-2E family transporter -
QNH74_RS02990 576114..577343 + 1230 WP_023370895.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 561809..580413 18604


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T296644 WP_012027435.1 NZ_OX352806:572468-572728 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT296644 WP_012775256.1 NZ_OX352806:572245-572466 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References