Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5782457..5783082 Replicon chromosome
Accession NZ_OX352324
Organism Pseudomonas sp. MM221

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OM991_RS27080 Protein ID WP_264360793.1
Coordinates 5782855..5783082 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OM991_RS27075 Protein ID WP_264360792.1
Coordinates 5782457..5782858 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM991_RS27055 (GLGCALEP_05626) 5779012..5780448 + 1437 WP_264360789.1 dual specificity protein phosphatase family protein -
OM991_RS27060 (GLGCALEP_05627) 5780445..5780876 + 432 WP_264360790.1 hypothetical protein -
OM991_RS27065 (GLGCALEP_05628) 5780887..5781510 + 624 WP_016497906.1 lysophospholipid acyltransferase family protein -
OM991_RS27070 (GLGCALEP_05629) 5781512..5782444 + 933 WP_264360791.1 phosphatidate cytidylyltransferase -
OM991_RS27075 (GLGCALEP_05630) 5782457..5782858 - 402 WP_264360792.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OM991_RS27080 (GLGCALEP_05631) 5782855..5783082 - 228 WP_264360793.1 type II toxin-antitoxin system HicA family toxin Toxin
OM991_RS27085 (GLGCALEP_05632) 5783282..5783557 - 276 WP_264360794.1 metal/formaldehyde-sensitive transcriptional repressor -
OM991_RS27090 (GLGCALEP_05633) 5783628..5784563 + 936 WP_264360795.1 CDF family Co(II)/Ni(II) efflux transporter DmeF -
OM991_RS27095 (GLGCALEP_05634) 5784660..5785004 + 345 WP_003258412.1 cupin domain-containing protein -
OM991_RS27100 (GLGCALEP_05635) 5785236..5786123 - 888 WP_264360796.1 3-hydroxyisobutyrate dehydrogenase -
OM991_RS27105 (GLGCALEP_05636) 5786133..5787659 - 1527 WP_264360797.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8305.43 Da        Isoelectric Point: 10.8123

>T296642 WP_264360793.1 NZ_OX352324:c5783082-5782855 [Pseudomonas sp. MM221]
MRSREVIQLIEADGWYEVDVKGSHHQFRHPTKRGRVKFPHPKSELPKGTVRSILKQAGLIQTGGVASTSVNGGDQ

Download         Length: 228 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14367.15 Da        Isoelectric Point: 4.4915

>AT296642 WP_264360792.1 NZ_OX352324:c5782858-5782457 [Pseudomonas sp. MM221]
MKFPVVLHKDEGSEYGVTVPDVPGCFSAGATVASALDNVQEALALHFEGLVADNEALPQATEIDAHVANPDYEGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAAIRELAL

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References