Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 5373112..5373740 Replicon chromosome
Accession NZ_OX352324
Organism Pseudomonas sp. MM221

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OM991_RS25180 Protein ID WP_234229625.1
Coordinates 5373558..5373740 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OM991_RS25175 Protein ID WP_264363461.1
Coordinates 5373112..5373534 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM991_RS25160 (GLGCALEP_05225) 5368303..5369016 - 714 WP_264360528.1 serine O-acetyltransferase -
OM991_RS25165 (GLGCALEP_05226) 5369188..5370528 + 1341 WP_264360529.1 PLP-dependent aminotransferase family protein -
OM991_RS25170 (GLGCALEP_05227) 5370632..5373073 + 2442 WP_264360530.1 penicillin acylase family protein -
OM991_RS25175 (GLGCALEP_05228) 5373112..5373534 - 423 WP_264363461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OM991_RS25180 (GLGCALEP_05229) 5373558..5373740 - 183 WP_234229625.1 type II toxin-antitoxin system HicA family toxin Toxin
OM991_RS25185 (GLGCALEP_05230) 5373948..5374964 + 1017 WP_264360531.1 ligase-associated DNA damage response exonuclease -
OM991_RS25190 (GLGCALEP_05231) 5374961..5376619 + 1659 WP_264360532.1 ATP-dependent DNA ligase -
OM991_RS25195 (GLGCALEP_05232) 5376780..5377894 + 1115 Protein_4946 M14 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6851.00 Da        Isoelectric Point: 11.0323

>T296641 WP_234229625.1 NZ_OX352324:c5373740-5373558 [Pseudomonas sp. MM221]
MKYSEFRRWLRGQGATFVAAKGSHFKVYLGNRQTIFPDHGAKEISEGLRKKILKDLGLKA

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15320.57 Da        Isoelectric Point: 4.9323

>AT296641 WP_264363461.1 NZ_OX352324:c5373534-5373112 [Pseudomonas sp. MM221]
IFEYPVVVHQEDGSVWVSCPDVPEMACAGDTSEEALFDAVDALESALSFYVDQKHAIPLPSAPTEGHPVVRLPALTAAKA
ALWNTMVAQKISKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALNVLGQRIELSVVAV

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References